The Ayurvedic with Muscular Dystrophy

This recent paper by Dr Mukesh D Jain offers having a main thrust medical software of care through research on Neuro-muscular disability having a focus on complementary Ayurvedic and Yogic tactic of treatment. medical evaluation involving Rasayana based Ayurvedic herbs together with Til-Mash Pinda swedana; Shat-Bala Prasarni Anuvasana Vasti and Yogic service yielded mixed results in 55 boys with Duchenne Muscular dystrophy (DMD); 19 with Becker’s Muscular Dystrophy (BMD) and 8 boys with Limb Girdle Muscular Dystrophy (LGMD). despite the fact that this Ayurvedic software didn’t have the hope for the genetic result of restoring dystrophin production, it do cut down serum CK levels. This could be a sign of decreased muscle damage. Since there was definite advancement in sensible ability, it is possible that complementary Ayurvedic treatment let lengthier survival with minimal disability. This hold a message to needy people and interested healthcare experts that Ayurvedic & Yogic help is available to patients afflicted by disabling issue with substantial burning of sensible mobility of muscles, ligaments and joints.

Pathogenesis: Dystrophy is a genetic defect and is a result of don’t have of just one muscle protein Dystrophin (1 of 3000 muscle proteins). DMD and BMD are due to different changes in the dystrophin gene, which contains data for a protein that is important for muscle tissue to work properly. This gene is located on the X chromosome. Dystrophin is localized to the sarcolemma in normal skeletal muscle, but is completely absent in muscle from DMD patients (8). typically disease is inherited but is also a result of spontaneous mutation exceeding 30% of the time. every child of the carrier mother has a 50% opportunity of inheritance of Muscular dystrophy. Though ladies can be carriers, exceeding 80% show no muscular dystrophy related symptoms. At present a hypothesis postulates a defect in the sarcolemma membrane which allows a substance (or substances), as still unknown but which could possibly be calcium, to enter the muscle fiber too freely, and there to trigger neutral proteases which, in turn, maintain an too much degree of muscle catabolism and lead to muscle fiber necrosis.

No treatment is at present known in any system of medicine which has any definite influence upon muscular dystrophy. The absence of distinct treatment for muscular dystrophy makes it all the greater important to consider complementary and alternative approaches of treatment. In India, the Dystrophy boys always seek Ayurvedic help in the hope for some relief. The Ayurvedic treatment involving Rasayana party of herbo-mineral or gold based medicine, yogic service and distinct Panch karma procedures have proven definite protective influence and lengthier survival upon muscular dystrophy. Ayurvedic Acharyas carefully consider this issue as adibala-pravrit Mamsa-vata-kshaya due to srotorodha. there’s depletion of Mamsagni paving the way of Ama formation. It is followed by vitiation of Kapha dosha. although srotorodha produces hypertrophy in particular region, it also manifests as first prokopa and then depletion of Vata element. This complicated pathogenesis is responsible for progressive wasting and necrosis of the affected muscle fibers.

Ayurveda visualizes 13 main sorts of Agnis (enzyme complex) which are responsible for the method of metabolism. every of seven dhatus has individual dhatvagnis. The increase or decrease of a particular dhatus depends upon the increase or decrease of respective dhatvagnis. According to Charak, Mamsa-kshaya might be present when there’s prolonged majjagata kupita Vata. This is always followed by depletion of Vata element. It is genetic predisposition (Beeja dosha) that convert physiological Vata component in to pathological morbidity. The srotodushti (? Sarcolemma membrane defect) is responsible for the mamsa dhatu kshaya.

The strategy of Dosha-Dhatu-Mala (D. D. M) is special in Ayurveda. The dhatus are those ingredients which are retained by the body and always rejuvenated or replenished. Ras-Rakta-Mamsa-Meda-Asthi-Majja and Sukra are seven dhatus which develops in human body in a fixed, sequential fashion one in the other. every succeeding dhatu is a metabolic refinement of the previous dhatu and get nourished by it. The first dhatu, Rasa (nutrient fluid) is the metabolic finish product of the digestion that takes place within gastro-intestinal tract. The Rasa dhatu must be metabolized in to Rakta dhatu. The Mamsa dhatu comes from Rakta dhatu as well as in turn, give rise to Meda dhatu. The Asthi dhatu is the merchandise of Meda dhatupaka that contains Majja dhatu that is certainly the prime seat of Vata element.

We realize that Vata (Prana) and Rakta dhatu are two main life sustaining elements in the body. The Vata continues to be attributed like genetic material that carries life data essential for different activities. The Rakta dhatu is the basis of biological sway that provides nutrition at cell level and paves the way of excretion of metabolic toxins. The driving sway past Rakta dhatu is Vata component which circulates itself to cell level together with Rakta. The conjoint blood circulation of both Rakta and Vata is manifestation of life (Prana). This Prana is responsible for the contraction and relaxation of muscle fibers or muscular activity. It means we now have to focus our consideration on the dhatvagnis paka of Rasa-Rakta-Mamsa and Meda dhatus besides Asthi and Majja dhatus. In this context Ayurvedic Rasayana treatment has significant role to play. (16, 17) Ancient Ayurvedic physicians experienced developed certain dietary and therapeutic actions to arrest/delay degeneration method and rejuvenating whole sensible dynamics of the body system. This revitalization and rejuvenation is known for the reason that ‘Rasayana Chikitsa’ (rejuvenation therapy). Rasayana are special ayurvedic assets that increase enzymatic essence of every dhatu starting from Rasa dhatu. Ayurveda uses organic mineral and metallic resource because of this purpose. Traditionally, Rasayana drugs are used against a plethora of seemingly diverse disorders with no patho-physiological connections according to modern medicine. Though, this party of plants generally possesses powerful antioxidant activity, only several have been investigated in detail. Neurodegenerative diseases have been reported as reactive oxygen species mediated and several Rasayana plants with potent antioxidant activity have been documented by countless investigators . The pure gold bhasma in low dose continues to be used effectively in the management of degenerative diseases of mamsa and Majja dhatu. Certain Ayurvedic herbs known for their Rasayana effects are now being scientifically verified for their possible result in the management of Muscular dystrophy. The nicely known herb Curcuma longa continues to be widely investigated for the immuno-localization and activation of nuclear factor-
{Kappa}B in polymyositis, dermatomyositis, and Duchenne muscular dystrophy (DMD). Data service the hypothesis that NF-?B contributes to the perpetuation of the dystrophic harm and show that its blockade produces beneficial effects on functional, biochemical, and morphological parameters. These new findings might have medical implications for the pharmacological treatment of patients with Muscular dystrophy. Withania somnifera is amazing ayurvedic herb that is widely used for stress, stamina and mental faculties functions. It contains Withanolide that is certainly anti-inflammatory; induces significant regeneration of axons, dendrites, pre-synapses and post-synapses in the neurons. It suppresses totally free radical generation; It also ameliorates neuronal dysfunction. The cardiac problems linked to some forms of muscular dystrophy sometimes need treatment. Terminalia Arjuna has remarkable cardio protective, heart muscle building up properties. Current medical research has proved that plant contains distinct medically active constituents namely triterpine glycosides like arjunetosides I, II, III, IV, arjunine and arjunetein, phytosterols, full of vitamins and minerals like calcium, magnesium, zinc and copper. Regular use of Arjuna improves pumping activity of heart, improves cardiac muscle strength, decrease in LDL cholesterol levels. It continues to be reported to possess protective cardiovascular and hypolipidemic properties. Similarly Tinospora cordifolia have been utilized in general debility, digestive disturbances, burning of appetite and fever in children. it’s also an useful immunostimulant. Its principal constituents are tinosporine, tinosporide, cordifolide, and cordifol. The plant is utilized in Ayurvedic Rasayana to enhance the immune system and the body’s resistance to infections . Praval being a natural resource of rich calcium, calcined Coral is widely utilized in ayurvedic medicine like a supplement in the treatment of variety of bone metabolic disorders linked to calcium deficiency. Praval bhasma is useful in the prevention of calcium deficient spinal contractures and bone deformities .

Usually Rasayana molecule does not work without purificatory procedures. The deepana, pachana method must be strengthened, the dosha must be balanced and metabolic toxins must be eliminated from dhatus through Panch karma procedures in order for Rasayana molecule to work (33), (35). Yogic service is always found practical in the management of Muscular dystrophy. Pawanamuktasa sequence of Yoga Asanas and Bhastrica Pranayama are important, particularly once the dystrophy has progressed for several years. Deep inhaling and laughing is often recommended to optimize respiratory care.

Material & Methods: Keeping in view the complicated pathogenesis involved in Muscular dystrophy, a special Ayurvedic Rasayana supplement was developed using deepan-pachan-srotorodhahara and mamsa dhatu vardhak Ayurvedic resources. The supplement developed and named as Mamsagni Rasayana. It combines the proven beneficial results of Curcuma longa, Withania somnifera, Tinospora cordifolia, Terminalia Arjuna, calcined Coral (Praval) and Gold bhasma, all processed in fresh juice of Aloe Vera barbendensis. The dose of the Mamsagni Rasayana was fixed 20 mg every kilo body weight. The medicine was administered orally in two equal doses following meal with 100 ml of milk for a period of half a dozen months.

Over 100 cases of Muscular dystrophy were enrolled at Panch Karma Clinic of Central clinical Institute, Bhilai and addressed while in March 1999 and September 2004. we now have selected complete 28 DMD boys, 19 BMD boys and 8 LMGD boys for inclusion in our medical study. All the Dystrophy boys were subjected to two weeks Panch karma procedures before administration of oral Mamsagni Rasayana together with Yogic service for half a dozen months. The treatment agenda consisting of (i) Modified Til-Mash Pinda Swedana using fresh leaves of Tejapatra ( Cinnamomum tamala ), Nirgundi (Vitex negundo ) and sprouted Methi ( Trigonella foenum ) seeds as additional ingredients to Til, Masha, unpolished rice and wheat bran, all cooked in the decoction of Bala ( Sida cordifolia ), Ashwagandha ( Withania somnifera ) and milk. (ii) Anuvasana Vasti with Shatbala-Prasarni oil. A blend of Sesame Oil 80%, Soya oil 10% and Castor oil 10% was used as bottom oil which was medicated by common method. The principal herbs utilized in the oil preparation are Shatavari (Asparagus racemosus), Bala (Sida cordifolia), and Ashwagandha (W. somnifera), and Nirgundi (Vitex negundo), and Haridra (Curcuma domestica), and Daru Haridra (Berberis aristata), and Mustaka (Cyperus rotundus), and Barbreng (Embelia ribes), and Mamsa Rohini: (Soymida febrifuda). These herbs are used as Neuro-muscular tonic and Vata balancing properties.

Observation & Results: In our study, the motor features were evaluated using complete motor score, upper and lower extremity purpose grades and timed purpose tests. Disability was quantitated with Barthel index. youngsters were found to have disabilities in multiple spheres of life, which were substantially motivated by the motor power. Barthel index was practical in identifying and quantifying distinct areas of disabilities in these children.
It was noticed that degeneration of muscle fibers was arrested following half a dozen weeks of administration of Mamsagni Rasayana. This was presumed on the basis of reduced CK level in blood. All the Dystrophy boys who completed medical analyze showed definite sign of advancement these kinds of as: (i) excess weight loss, (ii) Decrease in walking problems and (iii) Decrease in the severity of contractures and scoliosis. However DMD boys have proven quite slow progress.

Discussion: Today we realize that muscle degenerative wasting conditions in young patients are a result of defect in genes for the muscle proteins. Most of these proteins appear to experience a role in supporting the framework of muscle fibers, despite the fact that some play a role of biochemical enzymes. DMD and BMD are a result of don’t have of dystrophin protein. The Ayurvedic Rasayana drugs are nicely known for their result to delay / slow or change the progressive muscular degeneration. Some of the ingredients of Mamsagni Rasayana have been scientifically verified for their possible protective influence in muscular dystrophy. The Mamsagni Rasayana is designed to boost Mamsagni at muscle muscle level. It balances the Vata derangement due to Ama and therefore retards the muscular degeneration due to Ama (fat deposition). The Til-Masha Pinda Swedana stabilizes and improves the membrane defect removes the extra fat in the tissue. The Anuvasana Vasti balances the Vata element. The Yogic service of Pawan Muktasana sequence decrease the contractures, a issue often linked to muscular dystrophy in which shortened muscles all-around joints cause abnormal and sometimes painful positioning of the joints. In addition, Pawan Muktasana together with certain other Asanas for example Bhujangasana might avoid or delay scoliosis, or curvature of the spine. The Bhastrika Pranayama might service Cardio- Respiratory system and might enhance method of beta-oxidation at cell level. Since we now have noticed enhanced sensible capability along having a fall in serum Creatine kinase (CK) level it means there’s check on further muscle destruction.

Summary:

Muscular dystrophies are genetic disorders with no satisfactory treatment in any system of medicine. this is a progressive muscle-wasting disease due to a mutation in the dystrophin gene and the consequential protein deficiency in muscle. It results in chronic swelling and serious skeletal muscle degeneration. How the don’t have of the sarcolemma protein dystrophin provides rise to the final disease status is still not clear. Several evidences recommend a role of deregulation of NF-kappa in muscular dystrophy. Nuclear element kappa-B blockade reduces skeletal muscle degeneration and enhances muscle function. Regulation & handle of NF?B is therefore important. Ayurvedic Til-Mash Pinda Swedana treatment together with Rasayana herbo-mineral assets should be investigated in the lumination of possible influence on Sarcolemma membrane and NF?B: blockade. In this context targeted research is necessary to discover safe ayurvedic herbs, Yogic techniques and Panch karma procedures to further enhance complementary tactic of Ayurveda. The Ayurvedic software is practical in the lengthy phrase management of muscular dystrophies. there’s further need of controlled scientific studies on a big scale with enhanced analyze design and assessment techniques.

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2 thoughts on “The Ayurvedic with Muscular Dystrophy

  1. U.Remashan

    Respected Doctor,I am U.Remashan aged 50 belong to a poor family.My y sister & I have been suffering from “LIMB GIRDLE MUSCULAR DYSTROPHY “for more than 30 years.now we are in a pitiable conditions.I underwent thorough check up at SREE CHITHRA ,TVM ,KERALA (op no 9902452,12 05 99 2 19 05 99)Would U plse suggest medicines give atleast some relief ?U REMASHAN UNNIRI HOUSE KATALAYITHERU NALUMUKKE CHIRAKKAL KANNUR KERALA 670011

  2. Hind

    My husband has LGMD ,he’s keen to volenteer of trial of this treatement
    if this is possible please e mail me
    thank you

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