Tadalafil (Cialis) As Treatment for BMD

Sinai investigators funded through the Muscular Dystrophy Association are registering two dozen ambulatory men with Becker muscular dystrophy for any medical trial of tadalafil (Cialis) being a remedy for the progressive muscle disease. The randomized, placebo-controlled efficacy analyze will examine the outcomes of acute tadalafil dosing on muscle blood circulation during a bout of exercise.

About 18 million men have been treated with Cialis considering its introduction in 2003 by Eli Lilly and Company.

“Tadalifil has been proven to raise blood circulation in muscles, and it has the potential to aid people with muscular dystrophy,” points out Valerie Cwik, M.D., MDA Executive Vice President – study and Medical Director.

“We are pleased that the Cedars-Sinai Medical middle team led by Dr. Ronald Victor is undertaking a short-term medical trial of tadalafil in Becker muscular dystrophy,” adds Cwik, “especially considering latest findings released through the journal Nature showed that dystrophic mice treated with tadalafil have been able to perform significantly more exercise with less muscle injury.”

In the initial phase of the study, men years 18-55 with and with no Becker muscular dystrophy will undergo blood chemistry tests, DNA analysis, MRI scans of these forearm muscles before and after exercise, as effectively as ultrasound studies of blood circulation before and after handgrip exercise. Results will be utilised to determine which participants ideal fulfill analyze standards for the trial’s medicine phase.

In the trial’s medicine phase, twenty-four men with Becker muscular dystrophy will repeat the testing after remedy with tadalafil. To inquire about participating in the study, please phone call 310-248-8080. Participants could be compensated.

“This is an thrilling future step in the study I have been performing for 25 years, since we don’t must create a new drug – the drug already exists,” Victor says. “We now possess the opportunity to understand if tadalafil can supply some hope of enhancing the lifestyles of sufferers and allow them to do significantly more exercise with less injury.”

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